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1

Identification of a Universal VHH Framework to Graft Non-canonical Antigen-binding Loops of Camel Single-domain Antibodies

Dirk Saerens, Mireille Pellis, Remy Loris, Els Pardon, Mireille Dumoulin, André Matagne, Lode Wyns, Serge Muyldermans, Katja Conrath

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 539 KB

english, 2005

2

Comparison of llama VH sequences from conventional and heavy chain antibodies

Khoa Bang Vu, Mehdi Arbabi Ghahroudi, Lode Wyns, Serge Muyldermans

Journal:

Molecular Immunology

Year:

1997

Language:

english

File:

PDF, 1.24 MB

english, 1997

3

Kinetics and active site dynamics ofStaphylococcusaureusarsenate reductase

Joris Messens, José C. Martins, Elke Brosens, Karolien Van Belle, Doris M. Jacobs, Rudolph Willem, Lode Wyns

Journal:

JBIC Journal of Biological Inorganic Chemistry

Year:

2002

Language:

english

File:

PDF, 283 KB

english, 2002

4

Weak protein-protein interactions in lectins: the crystal structure of a vegetative lectin from the legume Dolichos biflorus

Lieven Buts, Minh-Hoa Dao-Thi, Remy Loris, Lode Wyns, Marilynn Etzler, Thomas Hamelryck

Journal:

Journal of Molecular Biology

Year:

2001

Language:

english

File:

PDF, 426 KB

english, 2001

5

Crystallographic Study of Glu58Ala RNase T1.cntdot.2'-Guanosine Monophosphate at 1.9-.ANG. Resolution

Pletinckx, Jurgen, Steyaert, Jan, Choe, Hui Woog, Heinemann, Udo, Wyns, Lode, Zegers, Ingrid

Journal:

Year:

1994

Language:

english

File:

PDF, 1.32 MB

english, 1994

6

Crystallization of glycosylated and nonglycosylated phytohemagglutinin-L

Dao-Thi, Minh-Hoa, Hamelryck, Thomas W., Poortmans, Freddy, Voelker, Toni A., Chrispeels, Maarten J., Wyns, Lode

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1996

Language:

english

File:

PDF, 392 KB

english, 1996

7

Functional Interactions among the His40, Glu58 and His92 Catalysts of Ribonuclease T1 as Studied by Double and Triple Mutants

Jan Steyaert, Lode Wyns

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 755 KB

1993

8

Carbohydrate binding, quaternary structure and a novel hydrophobic binding site in two legume lectin oligomers fromDolichos biflorus

Thomas W Hamelryck, Remy Loris, Julie Bouckaert, Minh-Hoa Dao-Thi, Gerard Strecker, Anne Imberty, Elias Fernandez, Lode Wyns, Marilynn E Etzler

Journal:

Journal of Molecular Biology

Year:

1999

Language:

english

File:

PDF, 2.07 MB

english, 1999

9

Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity

Abel Garcia-Pino, Sreeram Balasubramanian, Lode Wyns, Ehud Gazit, Henri De Greve, Roy D. Magnuson, Daniel Charlier, Nico A.J. van Nuland, Remy Loris

Journal:

Year:

2010

Language:

english

File:

PDF, 1.28 MB

english, 2010

10

The structural organization of dinudeosomes and oligonucleosomes. Electric dichroism and birefringence study

Houssier, Claude, Lasters, Ignace, Muyldermans, Serge, Wyns, Lode

Journal:

Nucleic Acids Research

Year:

1981

Language:

english

File:

PDF, 842 KB

english, 1981

11

Heterologous expression, purification and characterisation of the extracellular domain of trypanosome invariant surface glycoprotein ISG75

Thao Tran, Philippe Büscher, Guy Vandenbussche, Lode Wyns, Joris Messens, Henri De Greve

Journal:

Journal of Biotechnology

Year:

2008

Language:

english

File:

PDF, 725 KB

english, 2008

12

Influence of histones H1/H5 on the DNA coiling in the nucleosome — electric dichroism and birefringence study

Claude Houssier, Ignace Lasters, Serge Muyldermans, Lode Wyns

Journal:

International Journal of Biological Macromolecules

Year:

1981

Language:

english

File:

PDF, 783 KB

english, 1981

13

Structure of Chymopapain at 1.7 Å Resolution †

Maes, Dominique, Bouckaert, Julie, Poortmans, Freddy, Wyns, Lode, Looze, Yvan

Journal:

Year:

1996

Language:

english

File:

PDF, 336 KB

english, 1996

14

Coupling of Domain Swapping to Kinetic Stability in a Thioredoxin Mutant

Abel Garcia-Pino, Sergio Martinez-Rodriguez, Khadija Wahni, Lode Wyns, Remy Loris, Joris Messens

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 887 KB

english, 2009

15

Reduced Global Cooperativity is a Common Feature Underlying the Amyloidogenicity of Pathogenic Lysozyme Mutations

Mireille Dumoulin, Denis Canet, Alexander M. Last, Els Pardon, David B. Archer, Serge Muyldermans, Lode Wyns, Andre Matagne, Carol V. Robinson, Christina Redfield, Christopher M. Dobson

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 897 KB

english, 2005

16

Interplay Between Ion Binding and Catalysis in the Thioredoxin-coupled Arsenate Reductase Family

Goedele Roos, Lieven Buts, Karolien Van Belle, Elke Brosens, Paul Geerlings, Remy Loris, Lode Wyns, Joris Messens

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 816 KB

english, 2006

17

Differential association of linker histones H1 and H5 with telomeric nucleosomes in chicken erythrocytes

Muyldermans, Serge, Jonge, Jan De, Wyns, Lode, Travers, Andrew A.

Journal:

Nucleic Acids Research

Year:

1994

Language:

english

File:

PDF, 1.63 MB

english, 1994

18

The coordination of 5′-derivatives of adenosine to vanadate

Jens Richter, Dieter Rehder, Lode Wyns, A. Haikal

Journal:

Inorganica Chimica Acta

Year:

1995

Language:

english

File:

PDF, 358 KB

english, 1995

19

Thiol pegylation facilitates purification of chymopapain leading to diffraction studies at 1.4 Å resolution

Mohamed Azarkan, Dominique Maes, Julie Bouckaert, Minh-Hoa Dao Thi, Lode Wyns, Yvan Looze

Journal:

Journal of Chromatography A

Year:

1996

Language:

english

File:

PDF, 317 KB

english, 1996

20

Recognition of antigens by single-domain antibody fragments: the superfluous luxury of paired domains

Serge Muyldermans, Christian Cambillau, Lode Wyns

Journal:

Trends in Biochemical Sciences

Year:

2001

Language:

english

File:

PDF, 301 KB

english, 2001

21

Novel structures of plant lectins and their complexes with carbohydrates

Julie Bouckaert, Thomas Hamelryck, Lode Wyns, Remy Loris

Journal:

Current Opinion in Structural Biology

Year:

1999

Language:

english

File:

PDF, 605 KB

english, 1999

22

Scatter analysis of discrete-sized chromatin fragments favours a cylindrical organization

Ignace LASTERS, Lode WYNS, Serge MUYLDERMANS, John P. BALDWIN, George A. POLAND, Colin NAVE

Journal:

Year:

1985

Language:

english

File:

PDF, 753 KB

english, 1985

23

Two crystal forms of the lentil lectin diffract to high resolution

Remy Loris, John Lisgarten, Dominique Maes, Richard Pickersgill, Fritjof Körber, Colin Reynolds, Lode Wyns

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 299 KB

english, 1992

24

A Folding Switch Regulates the Phd/doc Operon by Conditional Cooperativity

Pino, Abel Garcia, Wyns, Lode, Loris, Remy

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 67 KB

english, 2009

25

Subsite interactions of ribonuclease T1: viscosity effects indicate that the rate-limiting step of GpN transesterification depends on the nature of N

Steyaert, Jan, Wyns, Lode, Stanssens, Patrick

Journal:

Year:

1991

Language:

english

File:

PDF, 607 KB

english, 1991

26

Hydrolysis of a slow cyclic thiophosphate substrate of RNase T1 analyzed by time-resolved crystallograph

Zegers, Ingrid, Loris, Remy, Dehollander, Gillis, Haikal, Abdel Fattah, Poortmans, Freddy, Steyaert, Jan, Wyns, Lode

Journal:

Natural Structural Biology

Year:

1998

File:

PDF, 704 KB

1998

27

Reconsidering the energetics of ribonuclease catalysed RNA hydrolysis

Stefan Loverix, Georges Laus, José C. Martins, Lode Wyns, Jan Steyaert

Journal:

Year:

1998

Language:

english

File:

PDF, 134 KB

english, 1998

28

Loss of splice consensus signal is responsible for the removal of the entire CH1 domain of the functional camel IGG2A heavy-chain antibodies

Viet Khong Nguyen, Raymond Hamers, Lode Wyns, Serge Muyldermans

Journal:

Molecular Immunology

Year:

1999

Language:

english

File:

PDF, 275 KB

english, 1999

29

Tri-n-butyltin 2,6-Difluorobenzoate, a Unique Macrocyclic Tetramer Containing a 16-Membered Sn4C4O8 Ring, and Other Related Compounds

Gielen, Marcel, El Khloufi, Abdelaziz, Biesemans, Monique, Kayser, Francois, Willem, Rudolph, Mahieu, Bernard, Maes, Dominique, Lisgarten, John N., Wyns, Lode

Journal:

Organometallics

Year:

1994

Language:

english

File:

PDF, 702 KB

english, 1994

30

Homo- and heteronuclear two-dimensional NMR studies of the globular domain of histone H1: Sequential assignment and secondary structure

Cerf, Corinne, Lippens, Guy, Muyldermans, Serge, Segers, Alain, Ramakrishnan, V., Wodak, Shoshana J., Hallenga, Klaas, Wyns, Lode

Journal:

Year:

1993

Language:

english

File:

PDF, 685 KB

english, 1993

31

TIM Crystals Grown by Capillary Counterdiffusion: Statistical Evidence of Quality Improvement in Microgravity †

Evrard, Christine, Maes, Dominique, Zegers, Ingrid, Declercq, Jean-Paul, Vanhee, Celine, Martial, Joseph, Wyns, Lode, Weerdt, Cécile Van De

Journal:

Crystal Growth & Design

Year:

2007

Language:

english

File:

PDF, 1.04 MB

english, 2007

32

Crystal structure determination and refinement at 2.3-.ANG. resolution of the lentil lectin

Loris, Remy, Steyaert, Jan, Maes, Dominique, Lisgarten, John, Pickersgill, Richard, Wyns, Lode

Journal:

Year:

1993

Language:

english

File:

PDF, 1.52 MB

english, 1993

33

1H,13C and15N assignments of a camelid nanobody directed against human α-synuclein

Anneleen Vuchelen, Elizabeth O’Day, Erwin De Genst, Els Pardon, Lode Wyns, Mireille Dumoulin, Christopher M. Dobson, John Christodoulou, Shang-Te Danny Hsu

Journal:

Biomolecular NMR Assignments

Year:

2009

Language:

english

File:

PDF, 203 KB

english, 2009

34

Dissection of the ribonuclease T1 subsite : The transesterification kinetics of Asn36Ala and Asn98Ala ribonuclease T1 for minimal dinucleoside phosphates

Jan STEYAERT, Abdel F. HAIKAL, Patrick STANSSENS, Lode WYNS

Journal:

Year:

1992

Language:

english

File:

PDF, 523 KB

english, 1992

35

The structures of rnase a complexed with 3′-CMP and d(CpA): Active site conformation and conserved water molecules

Ingrid Zegers, Dominique Maes, Minh-Hoa Dao-Thi, Lode Wyns, Freddy Poortmans, Rex Palmer

Journal:

Protein Science

Year:

1994

Language:

english

File:

PDF, 2.18 MB

english, 1994

36

Interplay Between Metal Binding and cis/trans Isomerization in Legume Lectins: Structural and Thermodynamic Study of P. angolensis Lectin

Abel Garcia-Pino, Lieven Buts, Lode Wyns, Remy Loris

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 829 KB

english, 2006

37

Structural and Thermodynamic Characterization of Pre- and Postpolymerization States in the F4 Fimbrial Subunit FaeG

Inge Van Molle, Kristof Moonens, Abel Garcia-Pino, Lieven Buts, Maia De Kerpel, Lode Wyns, Julie Bouckaert, Henri De Greve

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 1.23 MB

english, 2009

38

Study of the Structural and Dynamic Effects in the FimH Adhesin upon α- d -Heptyl Mannose Binding

Vanwetswinkel, Sophie, Volkov, Alexander N., Sterckx, Yann G. J., Garcia-Pino, Abel, Buts, Lieven, Vranken, Wim F., Bouckaert, Julie, Roy, René, Wyns, Lode, van Nuland, Nico A. J.

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.82 MB

english, 2014

39

How Thioredoxin Dissociates Its Mixed Disulfide

Roos, Goedele, Foloppe, Nicolas, Van Laer, Koen, Wyns, Lode, Nilsson, Lennart, Geerlings, Paul, Messens, Joris, Böckmann, Rainer A.

Journal:

PLoS Computational Biology

Year:

2009

Language:

english

File:

PDF, 1.43 MB

english, 2009

40

Purification of an oxidation-sensitive enzyme, pI258 arsenate reductase from Staphylococcus aureus

Joris Messens, José C. Martins, Ingrid Zegers, Karolien Van Belle, Elke Brosens, Lode Wyns

Journal:

Journal of Chromatography B

Year:

2003

Language:

english

File:

PDF, 1.85 MB

english, 2003

41

The affinity of the FimH fimbrial adhesin is receptor-driven and quasi-independent of Escherichia coli pathotypes

Julie Bouckaert, Jenny Mackenzie, José L. De Paz, Beatrice Chipwaza, Devapriya Choudhury, Anton Zavialov, Karin Mannerstedt, Jennifer Anderson, Denis Piérard, Lode Wyns, Peter H. Seeberger, Stefan Osc

Journal:

Molecular Microbiology

Year:

2006

Language:

english

File:

PDF, 498 KB

english, 2006

42

The molecular structure of [1,2,5]oxadiazolo[3?,4? : 3,4]-5?-pregn-16-en-20-one (HS974). Crystal structure and NMR investigations

Maes, Dominique, Van Cauteren, Marc, Wyns, Lode, Lisgarten, John, Palmer, Rex, Lisgarten, David, Willem, Rudolph, Biesemans, Monique, Kayser, Fran�ois

Journal:

Journal of the Chemical Society Perkin Transactions 2

Year:

1992

Language:

english

File:

PDF, 811 KB

english, 1992

43

Intervening with Urinary Tract Infections Using Anti-Adhesives Based on the Crystal Structure of the FimH–Oligomannose-3 Complex

Wellens, Adinda, Garofalo, Corinne, Nguyen, Hien, Van Gerven, Nani, Slättegård, Rikard, Hernalsteens, Jean-Pierre, Wyns, Lode, Oscarson, Stefan, De Greve, Henri, Hultgren, Scott, Bouckaert, Julie, Zha

Journal:

Year:

2008

Language:

english

File:

PDF, 591 KB

english, 2008

44

A catalytic function for the structurally conserved residue Phe 100 of ribonuclease T1

Jan Doumen, Malgorzata Gonciarz, Ingrid Zegers, Remy Loris, Lode Wyns, Jan Steyaert

Journal:

Protein Science

Year:

1996

Language:

english

File:

PDF, 3.15 MB

english, 1996

45

Structure of a membrane-based steric chaperone in complex with its lipase substrate

Pauwels, Kris, Lustig, Ariel, Wyns, Lode, Tommassen, Jan, Savvides, Savvas N, Van Gelder, Patrick

Journal:

Nature Structural and Molecular Biology

Year:

2006

Language:

english

File:

PDF, 247 KB

english, 2006

46

How Thioredoxin can Reduce a Buried Disulphide Bond

Joris Messens, Inge Van Molle, Peter Vanhaesebrouck, Maya Limbourg, Karolien Van Belle, Khadija Wahni, José C Martins, Remy Loris, Lode Wyns

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.10 MB

english, 2004

47

Investigation of the functional interplay between the primary site and the subsite of RNase T1: Kinetic analysis of single and multiple mutants for modified substrates

Jan Steyaert, Abdel Fattah Haikal, Lode Wyns

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1994

Language:

english

File:

PDF, 589 KB

english, 1994

48

Sequence-specific1H,15N and13C resonance assignments of the 23.7-kDa homodimeric toxin CcdB fromVibrio fischeri

Michal Respondek, Lieven Buts, Natalie De Jonge, Sarah Haesaerts, Remy Loris, Laurence Van Melderen, Lode Wyns, Klaus Zangger

Journal:

Biomolecular NMR Assignments

Year:

2009

Language:

english

File:

PDF, 216 KB

english, 2009

49

The Role of Surface Diffusion in the Growth Mechanism of Triosephosphate Isomerase Crystals

Sleutel, Mike, Vanhee, Celine, Van de Weerdt, Cécile, Decanniere, Klaas, Maes, Dominique, Wyns, Lode, Willaert, Ronnie

Journal:

Crystal Growth & Design

Year:

2008

Language:

english

File:

PDF, 2.49 MB

english, 2008

50

A Computational and Conceptual DFT Study on the Michaelis Complex of pI258 Arsenate Reductase. Structural Aspects and Activation of the Electrophile and Nucleophile

Roos, Goedele, Messens, Joris, Loverix, Stefan, Wyns, Lode, Geerlings, Paul

Journal:

Journal of Physical Chemistry B

Year:

2004

Language:

english

File:

PDF, 435 KB

english, 2004

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